Mojtaba Hajipour - Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran,
Atefeh Sarafan Sadeghi - Department of Food Hygiene and Aquaculture, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad,Mashhad, Iran,

Reported clinical findings indicate that omega-۳ fatty acids (eicosatetraenoic acid (EPA) and docosahexaenoicacid (DHA)) have anti-inflammatory and cardioprotective properties. In addition, vitamin C is a powerfulantioxidant that is thought to save you from low-density lipoprotein (LDL) oxidation. As, free radical damagebegins early in chronic kidney disease (CKD) progression and it is an important risk factor for increasedinflammatory status, CVD and its mortality, this study investigates the antioxidant impact of Vitamin C andOmega-۳ in hemodialysis (HD).Material and MethodsTo accomplish this narrative review, we searched ۴ Databases (PubMed, Web of Science, Scopus and googlescholar) based on the search strategy from ۲۰۱۰ to ۲۰۲۲ with the high sensitivity on September ۲۰۲۲ by followingMeSH keywords: " Vitamin C ", " Omega-۳ ", " cardiovascular disease ", " chronic kidney disease ", "Hemodialysis ".FindingsMost research indicates that omega-۳ fatty acids could act as an antioxidant rather than a pro-oxidant in severalcells, including vascular cells, diminishing inflammation, oxidative stress, and, in turn, the risk of atherosclerosisand degenerative disorders such as cardiovascular disease. Based on experiments and investigations scorbate actsthrough reducing other molecules, mostly transition-metal ions like ferric iron (Fe۳+) and copper, either at theactive site of enzymes or as free ions. Furthermore, In the presence of transition metals like iron, pro-oxidanteffects might result in an extra oxi- dative damage, and ascorbylation might contribute to the carbonyl stress.Some research reported administration of ۲۵۰ mg/day of intravenous (IV) vitamin C after HD sessions ۳ times aweek for ۱۲ weeks and total DHA ۶۰۰ mg and total EPA ۱۸۰۰ mg three times a week during dialysis treatment.ConclusionCurrent data indicate that vitamin C and omega-۳ have the potential to prevent CVD in children with HD.

Vitamin C, Omega-۳, cardiovascular disease, chronic kidney disease, hemodialysis