Stephen Adefegha - Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, P.M.B. ۷۰۴, Akure ۳۴۰۰۰۱, Nigeria
Ahmad Salawi - Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, ۴۵۱۴۲, Saudi Arabia
Akkarach Bumrungpert - Research Center of Nutraceuticals and Natural Products for Health & Anti-Aging, College of Integrative Medicine, Dhurakij Pundit University, Bangkok ۱۰۲۱۰, Thailand
Sepideh Khorasani - Department Food Science and Technology, Faculty Agriculture, Shahid Bahonar University of Kerman, ۲۲ Bahman Blvd., Kerman ۷۶۱۶۹۱۴۱۱۱, Iran
Sarabanou Torkaman - Australasian Nanoscience and Nanotechnology Initiative (ANNI), ۸۰۳۱ Monash University LPO, Clayton, Victoria ۳۱۶۸, Australia
M. Mozafari - Australasian Nanoscience and Nanotechnology Initiative (ANNI), ۸۰۵۴ Monash University LPO, Clayton, Victoria ۳۱۶۸, Australia
Elham Taghavi - Faculty of Fisheries and Food Science, Universiti Malaysia Terengganu, ۲۱۰۳۰ Kuala Nerus, Terengganu, Malaysia

Polyphenolic compounds are present in different parts of plants, including the root, stem, bark, leaves, seeds and fruits. They have been reported for their various biological functions including antimicrobial, antioxidant, anti-inflammatory, anticancer, antidiabetic, cardioprotective, and neuroprotective effects to mention a few, based on their interesting structures. The structure-function relationship of these polyphenolic compounds confers nutraceutical potentials on them, thus making them suitable for novel drug design and formulation of pharmaceutics. However, to preserve the structural properties of these polyphenolic compounds in biological systems, they have to be encapsulated in matrix of biopolymers. Hence, the need for the technology of nanoencapsulation that will enable the preservation and protection of the polyphenolic compounds from degradation and loss of potency. This review captures nanoencapsulation technology of polyphenolic compounds, their application in food and pharmaceutical industries, safety and biocompatibility. This also describes the health promotion and disease prevention of encapsulated polyphenolic compounds in animals and humans.

biopolymers, cardioprotective, Disease prevention, Encapsulation, Health promotion, Nanoencapsulation, Neuroprotective, polyphenolic compounds