Elevated Lipoprotein (a) and ۱۰-Year Risk of Cardiovascular Disease among Iranian Patients with Bipolar Disorder

Background:Bipolar disorder is associated with a high risk of cardiovascular disease. The aim of this study was to determine the elevated lipoprotein (a) level and ۱۰-year risk of cardiovascular disease among patients with bipolar disorder. Methods:This cross-sectional study was conducted on ۱۰۰ patients with bipolar disorder in Yazd province, Iran. Elevated lipoprotein (a) concentration was defined as the lipoprotein (a) level of greater than ۳۰ Mg/dL. The Framingham risk equation was used to estimate the ۱۰-year risk of cardiovascular disease. The data were analyzed using Chi-square or Fisher's exact test, and independent sample-t or Mann-Whitney test. Statistical significance level was set at p ≤ ۰.۰۵. Results:In this study, ۷۵ male (۷۵%) and ۲۵ female (۲۵%) patients with bipolar disorder were investigated. Based on the findings, smoking was significantly more prevalent among men than women (p <۰.۰۰۱). No statistically significant difference was observed between males and females with regard to the total cholesterol, high- and low-density lipoprotein cholesterol, systolic blood pressure, body mass index, and lipoprotein (a) (p>۰.۰۵). High levels of lipoprotein (a) were observed in ۴۱% of the participants. Most individuals (۷۷.۳%) were at low risk for developing cardiovascular disease in the next ۱۰ years. Conclusion:The findings suggest a high level of lipoprotein (a) among patients with bipolar disorder. Most participants were at a low risk for developing cardiovascular disease in the next ۱۰ years. Psychiatrists and health professionals should be informed about cardiovascular risk factors in bipolar patients and monitor them regularly for early detection.

Keywords:

Lipoprotein (a) , Cardiovascular disease , Bipolar Disorder