Mina Khosravi - Department of Clinical Pharmacy, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
Gholamreza Asadikaram - Neuroscience Research Center, Institute of Neuropharmacology, Department of Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Fatemeh Musavi Mehdiabadi - Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Naemeh Nikvarz - Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran

Background: Hempseed oil is a suitable source of alpha-linolenic acid, an omega-۳ polyunsaturated fatty acid. In this study, we aimed to evaluate the effects of hempseed oil on the plasma levels of inflammation markers interleukin-۶ and tumor necrosis factor-α in maintenance hemodialysis patients.Methods: This ۸-week single-blind randomized study was conducted on ۹۷ hemodialysis patients. Patients were randomly assigned to the hempseed oil (receiving ۲۰ ml of hempseed oil per day) or control (receiving no intervention) group. The plasma concentrations of interleukin-۶ and tumor necrosis factor-α were measured at baseline and at the end of the study.Results: The plasma concentrations of interleukin-۶ and tumor necrosis factor- α changed significantly in neither of the group. Furthermore, the comparison of changes in the concentrations of IL-۶ and TNF-α throughout the study showed no significant difference between the hempseed oil and control groups.Conclusion: Hempseed oil consumption did not decrease inflammation in the maintenance hemodialysis patients.

Hemodialysis, Hempseed oil, Cannabis oil, Inflammation, Interleukin-۶, Tumor necrosis factor-α