Narges Gholizadeh - Associate Professor of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Farzaneh Agha-Hosseini - Professor, Fellowship of Research Biology, Dental Research Center, Dental Research Institute & Department of Oral and Maxillofacial Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, the Academy of Medical Sciences, Tehran,
Hoda Barati - Assistant Professor of Oral Medicine, Faculty of Dentistry, Arak University of Medical Sciences, Arak, Iran
Bita Rohani - Associate Professor of Oral Medicine, Faculty of Dentistry, Aja University of Medical Sciences, Tehran, Iran

Pyodermatitis-pyostomatitis vegetans (PD-PSV) is an uncommon inflammatory mucocutaneous disease with unknown etiology. It is characterized by pustular and vegetating plaques on the skin and oral mucosa. When the oral mucosa is involved alone, it is called pyostomatitis vegetans. This disease is considered as an oral manifestation of inflammatory bowel diseases. In the present paper, we report a case of pyostomatitis vegetans in a ۲۳-year-old female patient with swelling of the lips and oral lesions. Our patient had simultaneously three important clinical symptoms, including the presence of intra-oral lesions, lip swelling, and gastrointestinal manifestations that may be suggestive of inflammatory bowel disease. Her oral manifestations improved with topical antifungal drug and local and systemic corticosteroids. In addition, the results of our extensive search in reliable scientific databases including Google and PubMed for articles (case reports and literature reviews) containing the keywords: ”pyostomatitis vegetans” and "pemphigus vegetans” in recent years are presented.

Inflammatory bowel diseases, Oral Manifestation, oral mucosa, Pemphigus vegetans