Behjat Kalantari Khandani - Assistant Professor, Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Sara Shafieipour - Assistant Professor, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Amir Mobasserfar - Assistant Professor, Department of Internal Medicine, Rafsanjan University of Medical Scienses, Rafsanjan, Iran
Mohammad Javad Zahedi - Professor, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Mohammad Hashemi - Professor, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Mohammad Mahdi Hayatbakhsh Abbasi - Professor, Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
Sodaif Darvish Moghadam - Professor, Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Background: Single nucleotide polymorphisms (SNPs) have been introduced as a new genomic source for cancer. Therefore, it was decided to conduct a study to evaluate the rs۳۷۴۶۴۴۴ polymorphism of miR-۴۹۹ in patients with colon cancer in comparison with healthy subjects. Methods: This case-control study was conducted to investigate rs۳۷۴۶۴۴۴ polymorphism of miR-۴۹۹ in blood samples of case and control groups. Patients with a confirmed diagnosis of cancer based on pathologic report were enrolled in the study as the case group and compared with healthy subjects. The level of significance was considered at p < ۰.۰۵. Result: The mean of DNA count in samples was ۶۳.۱۷± ۲۳.۵۱ that was significantly higher in the case group. The rs۳۷۴۶۴۴۴ polymorphism of miR-۴۹۹ was significantly higher in patients with cancer compared to the healthy subjects (P < ۰.۰۵). Conclusion: In this study, rs۳۷۴۶۴۴۴ polymorphism of miR-۴۹۹ was significantly higher in patients with colon cancer, which indicated that people with this polymorphism had a higher risk for malignancy.

Rs۳۷۴۶۴۴۴ Polymorphism miR, ۴۹۹ Colon Cancer