Synthesis and Biological Evaluation of ۴-hydroxychromenyl arylmethyl-۶-hydroxy pyrimidine-۲, ۴-dione Derivatives

Background: An efficient, promoted tri-component catalytic reaction between barbituric acid (or N,N-dimethyl barbituric acid), ۴-hydroxy coumarin, and a wide range of aryl aldehydes using zinc oxide nanowires (ZnO NWs) to obtain some new ۴-hydroxychromenylarylmethyl-۶-hydroxypyrimidine-۲,۴-diones is described. Method: The reactants were successfully condensed via three C-C bond formation by zinc oxide nanowires (ZnO NWs) as an efficient, environmentally safe and recyclable nano catalyst to produce target molecules. In addition, the biological effects of synthesized products by the use of DPPH and acyclovir as positive controls and also Hep-۲, vero cell, HSV-۱, and adenovirus as four applied cell lines have been evaluated. Results: The results showed that synthesized products have anti-oxidant, cytotoxic and anti-viral activities and can offer promising prospect as biologically active agents. Conclusion: This achievement in an efficient and eco-friendly synthesis of novel analogous of hybrid molecules in aqueous media with special biological properties may engross chemists and pharmacologists as well as pharmacists in future.

Keywords:

Synthesis , Ultrasound assisted , Bio-assay , Anti-oxidant , Cytotoxic , Anti-viral , Nano-catalyst