Non – Detection of HPV DNA in Prostatic Cancer and Benign Prostatic Hyperplasia: a case- control study in Kerman

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JKMU-25-1_009

تاریخ نمایه سازی: 19 دی 1401

Abstract:

Background: Different studies assessed the role of inflammation in malignancy of different organs. Prostatitis has been suggested as a cause of cancer and BPH. Till now, more than ۱۰۰ types of human Papilloma virus (HPV) are recognized including low and high-risk groups for carcinogenesis. Among them HPV-۱۶ and HPV-۱۸ have shown further association with cancer. Regarding the presence of E۶ and E۷ in HPV and ability for modification of basal epithelial cells, related role in prostate cancer (as well as cervical and genital malignancies) is hypothesized. The aim of this study was to determine the association of HPV-۱۶ and HPV-۱۸ with prostate cancer and malignancy degree. Methods: A total of ۷۵ consecutive paraffin-embedded blocks including ۵۰ samples with primary prostate cancer and ۲۵ samples with benign prostate hyperplasia (BPH) as control were studied. Amplisense kit was used for replication at real-time polymerase chain reaction (PCR) to determine genotypes of HPV-۱۶ and HPV-۱۸. DNA purity was assessed by Nano Drop. Results: The results of real-time PCR demonstrated that none of the samples of BPH and prostate cancer had amplification of HPV DNA. Conclusion: The results revealed that HPV-۱۶ and HPV-۱۸ are not causes of prostate cancer.

Authors

elham jafari

Assistant Professor, Pathology and Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran

Shariar Dabiri

Professor of Pathology, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Abbas Mortazaeizadeh

Researcher, Pathology and Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran

Ahmad Reza Sayadi

Assistant Professor, Social Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Sahar Amir Poor Rostami

Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

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