Rostam Seifaddini - Assistant Professor of Neurology, Neurology Research Center, Kerman University of Medical Science, Kerman, Iran
Hossein Ali Ebrahimi - Professor of Neurology, Neurology Research Center, Kerman University of Medical Science, Kerman, Iran
Farhad Iranmanesh - Professor of Neurology, Neurology Research Center, Kerman University Of Medical Science, Kerman, Iran
Mohammad Hadi Mohammadi - Resident of Neurology, Neurology Research Center, Kerman University Of Medical Science, Kerman, Iran

Introduction: There is still no finding available that can show the malignant clinical course in patients with middle cerebral artery stroke. The aim of this study was to compare Doppler ultrasound findings in patients with malignant and non-malignant middle cerebral artery stroke in order to obtain its prognostic value in detecting malignant course. Method: This cross-sectional study was conducted on ۴۰ patients with acute ischemic stroke in Shafa University Hospital Kerman, Iran, ۲۰۱۷. All patients were admitted within ۲۴ hours of onset of symptoms, and brain CT-scan was performed to confirm ischemic stroke. If more than ۵۰% of the middle cerebral artery showed signs of hypo density, it was considered massive MCA infarction (MMI), while others were excluded. In the first ۲۴ hours, trans cranial Doppler ultrasound was performed for all patients. Patients were then examined until discharge or death. If the case of fixed unilateral mydriasis in the clinical course or a displacement of more than ۵ mm in septum pellucidum in the control CT-scan on days ۳ to ۷ (depending on the changes in the consciousness level), m-MCAI was diagnosed. Data were analyzed using SPSS. Result: In the malignant cases, the mean PSV and MFV in MCA in the contralateral side of the lesion were significantly higher than the non-malignant cases. A significant increase in mean PSV and MFV in ACA in the contralateral side of the lesion was found in malignant compared to non-malignant cases (P=۰.۰۱). Significant difference was observed in terms of mean RI of ICA of contralateral side of the lesion between malignant and non-malignant cases (P=۰.۰۲). Conclusion: Our study showed increase in PSV and MFV in MCA and ACA in the contralateral side of the lesion in cases that lead to malignancy, which can be helpful in identifying early cases that advance to malignancy.

Dopplex sonography, Stroke, Prognosis