Mahsa Kalantari - Assistant professor, Department of Oral and Maxillofacial Pathology, School of Dentistry& Oral and Dental Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran
Molook Torabi - Associate professor, Department of Oral and Maxillofacial Pathology, School of Dentistry & Oral and Dental Diseases Research Center , Kerman University of Medical Sciences, Kerman, Iran

Approximately ۹۰% of all head and neck malignancies and ۹۴% of oral malignancies are squamous cell carcinoma (SCC). Tobacco smoking is considered as the most important causative agent for SCC. Despite aggressive and multidisciplinary treatment approaches, there has been no significant improvement in ۵-year survival over the past ۲۰ years. Several prognostic and predictive clinical, pathological and molecular factors have been introduced for SCC. We herein review some of these prognostic factors.