الهام جعفری - Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
احمد مظفر - Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
مهرداد شریعتی - Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
آرش پایه دار - Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran

Background and aim: Moclobemide (MCB) is an antidepressant that is metabolized in the liver and acts as a monoamine oxidase inhibitor. The aim of this study was to evaluate the effect of MCB on serum levels of hepatic transaminases, blood biochemical parameters and histopathological changes of liver in adult male rats. Materials and methods: Thirty two adult male Wistar rats were divided into ۴ groups of ۸. The control group did not receive any treatment, but the experimental groups (Exp) ۱, ۲ and ۳ received doses of ۱۶۰, ۳۲۰ and ۶۴۰ mg/kg MCB as oral gavage for ۲۸ days, respectively. At the end of the study, body weight, liver weight, serum levels of liver transaminases (ALT, AST) and blood biochemical parameters (ALP, total protein, Albumin, total and direct Bilirubin) were measured. Also, liver tissue was removed for histopathological examination. Results: The results of the study showed that body weight, liver weight and serum levels of total and direct Bilirubin in the experimental groups were not significantly different from the control group (p<۰.۰۵). Serum levels of ALT, AST and ALP in Exp۱ group did not show a significant difference with the control group (p>۰.۰۵) but in contrast, in Exp۲ and Exp۳ groups, a significant increase was observed (p<۰.۰۵). Serum levels of total protein and Albumin in Exp۱ and Exp۲ groups did not show a significant difference with the control group (p<۰.۰۵) but in contrast, in Exp۳ groups, there was a significant decrease (p<۰.۰۵). In all ۳ Exp groups, some degrees of necrosis and destruction of liver tissue were observed, and the maximum necrosis and destruction was observed at the maximum dose. Conclusion: Moclobemide causes changes in serum levels of hepatic transaminases, blood biochemical parameters and the destruction of liver tissue, especially at the maximum dose (۶۴۰ mg/kg) in male rats.

Moclobemide, Liver tissue, Liver enzymes, Depression, Rat, موکلوبماید, بافت کبد, آنزیم های کبدی, افسردگی, موش صحرایی