Investigating the level of drug resistance of Acinetobacter baumannii strains in the intensive care units of hospitals

Introduction: Acinetobacter are gram-negative bacteria that do not have the ability to ferment and are commonly involved in hospital infections. Acinetobacter as opportunistic hospital pathogens are resistant to a large number of antibiotics and are the cause of many infections such as bacteremia, pneumonia, meningitis, urinary tract infections and surgical wound infections.Materials and methods: During this study, ۶۰ isolates of Acinetobacter bomanii and ۴۶ isolates of other Acinetobacter species were studied. After identifying the species by using the methods of determining the sensitivity of the species to different antibiotics, it was done by using the disk diffusion method.Research findings:In this study, all isolates of Acinetobacter baumannii were resistant to the antibiotics ampicillin/sulbactam, imipenem, gentamicin, ceftazidime and ceftazidime-clavulanic acid, cefotaxime, cefotaxime/clavonic acid, amikacin, ceftriaxone, ciprofloxacin and nalidixic acid and all The isolates were sensitive to colistin and by the standard ATCC strain (PTCC ۱۸۵۵) BAA-۷۴۷ and the clinical isolates of Acinetobacter baumannii using agar disk diffusion method. Following the isolation and identification of antibiotic-resistant and beta-lactamase-producing Escherichia coli isolates by performing the golden test and phenotypic confirmation of combined discs (DDD-Test) in comparison to single discs without the presence of clavonic acid.Final conclusion: The results of this study showed that clinical isolates of Acinetobacter, especially Acinetobacter baumannii, show high resistance to antibiotics, especially third-generation cephalosporins and broad-spectrum penicillins.

Keywords:

Acinetobacter baumannii , hospital infection , concurrent antibiotic resistance , special care