Nady Braidy - Department of Psychiatry, Center for Healthy Brain Ageing, University of New South Wales, Sydney, Australia
Ali Zarrabi - Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, Türkiye
Sevgi Durna Dastan - Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, Türkiye
Taner Dastan - Department of Biochemistry, Faculty of Science, Sivas Cumhuriyet University, Sivas, Türkiye
Ali Raza Memon - Department of Biochemistry, Liaquat University of Medical & Health Sciences, Jamshoro Sindh, Pakistan

Stroke is a disease that can lead to death or long-term disability. Genetic polymorphisms in key genes can alter the risk of developing the disease. The aim of this study was to investigate the association of rs۱۸۰۰۴۷۰ polymorphism in the TGFB۱ gene with the risk of stroke in the Asian population by a meta-analysis approach. In this study, six eligible studies were included using a systematic search. The strength of the association of the polymorphism with the risk of stroke was assessed by estimating the odds ratio (OR) and ۹۵% confidence interval (CI). The results of our study showed that rs۱۸۰۰۴۷۰ with risk of stroke in seven genetic models’ allelic model, recessive model, dominant model, overdominant model, CC vs. TT, CC vs. CT, and CT vs. TT is not associated. Of course, there was significant heterogeneity among the included studies and there was no publication bias in the meta-analysis. Based on these results, rs۱۸۰۰۴۷۰ polymorphism cannot be considered a suitable biomarker for stroke risk in the Asian population, and further studies are needed to achieve more accurate results.

ischemic stroke, rs۱۸۰۰۴۷۰ polymorphism, TGFB۱ gene, Meta-analysis