An overview of the influence of germinal centers on antibody production
Publish place: Current Research in Medical Sciences، Vol: 5، Issue: 2
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_NHJ-5-2_007
تاریخ نمایه سازی: 4 بهمن 1401
Abstract:
Secretory antibodies produced by B lymphocytes mediate humoral immunity. B-cells develop after maturation in bone marrow from stem cells to obtain the necessary properties to identify and combat against pathogens. B lymphocytes settle in peripheral lymphoid tissues to interact with foreign antigens. The activation of B cells in the peripheral lymphoid tissues lead to the proliferation, differentiation, and production of memory B cells and antibody-secreting plasma cells. The production of memory B cells requires the formation of germinal centers that act as a site for affinity maturation and B cells acquire the necessary changes to detect antigens and produce long-lived plasma cells. In this review, we will focus on related mechanisms of germinal center formation and production of antibodies.
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Authors
Abolfazl Rahmani
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Masoud Baee
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Maryam Rostamtabar
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Fatemeh Davari
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Hamid Reza Nouri
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran