Electrochemical Sensing of Folic Acid in Presence of Ascorbic acid Using Carbon Paste Nano Composite Modified Electrode

In the present work, combination of unique properties of two nano material compounds, MgO nano paricles (MgO NPs) and multi-wall carbon nanotubes (MWCNT), and electrocatalytic activity of an oxadiazole derivative, ۳-(۵-(pyridine-۴-yl)-۱,۳,۴-oxadiazole-۲-ylthio)-۴- methylcyclohexa-۱,۳-diene-۱,۲-diol; POM, was used to fabricate a sensitive electrode (POM-MgO NPs-MWCNT-CPE) for electrochemical determination of folic acid. The electrochemical treatment of folic acid was studied in phosphate buffer solution (۰.۱ M, pH ۷) by means of common electrochemical techniques such as cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The sensitive fabricated electrode displayed good operating characteristics such as wide linear range and low detection limit for the determination of folic acid. Using the fabricated electrode, a wide linear dynamic range in concentration range ۰.۰۸-۶۵۰.۰ μM, and a limit of detection of ۰.۰۲ μM were found. Using the modified electrode, the two well distinguished peaks were recorded at ۱۱۰.۰ and ۲۰۹ mV for ascorbic acid and folic acid, respectively. Reliability and accuracy of the introduced electrode were studied in pharmaceutical and biological samples.

Keywords:

Carbon paste electrode , Oxadiazole derivative , Multiwall carbon nanotubes , Folic acid , Ascorbic acid