Trace Analysis of Niflumic Acid in Milk and Human Plasma by Ion-pair-based Vortex Assisted Dispersive Liquid-liquid Microextraction Combined with UV-Vis Spectrophotometry
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ANALCH-5-2_013
تاریخ نمایه سازی: 16 بهمن 1401
Abstract:
A simple, accurate and fast vortex-assisted dispersive liquid-liquid microextraction procedure has been developed for the extractive spectrophotometric determination of niflumic acid in biological samples. The method is based on the formation of an ion association complex between niflumic acid and methylene blue. The resulting ion-pair was extracted into dichloromethane and its absorbance was measured at ۶۵۵ nm. All experimental parameters affecting the analytical performance of the method such as pH, type and volume of buffer and extraction solvent, dye concentration, extraction time, ionic strength and interfering species were investigated. The calibration curve was linear in the range of ۵-۷۰ ng mL-۱ and the limit of detection (LOD) was found to be ۲.۸ ng mL-۱. The procedure was successfully applied for the determination of niflumic acid in human plasma and goat’s milk samples. The main advantages of the proposed method are rapidity, little solvent consumption, low cost and providing low LOD by the simple UV-Vis spectrophotometer.
Keywords:
Niflumic acid , Vortex-assisted dispersive liquid-liquid microextraction , UV-Vis spectrophotometry , Methylene blue , Milk , Human plasma
Authors
Zahra Ghoraba
School of Chemistry, Damghan University, Damghan, Iran
Behzad Aibaghi
School of Chemistry, Damghan University, Damghan, Iran
Ahmad Soleymanpour
School of Chemistry, Damghan University, Damghan, Iran
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