Effects of Selenium Nanoparticles on Biochemical Parameters and Histopathological Changes in Lead-intoxicated Rats
عنوان مقاله: Effects of Selenium Nanoparticles on Biochemical Parameters and Histopathological Changes in Lead-intoxicated Rats
شناسه ملی مقاله: JR_JHEHP-7-1_006
منتشر شده در در سال 1399
شناسه ملی مقاله: JR_JHEHP-7-1_006
منتشر شده در در سال 1399
مشخصات نویسندگان مقاله:
Mohammad Reza Hajinezhad - Department of Basic Veterinary Science, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran.
خلاصه مقاله:
Mohammad Reza Hajinezhad - Department of Basic Veterinary Science, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran.
Background: The present study aimed to investigate the protective effects of selenium nanoparticles in a lead-induced testicular toxicity model.
Methods: In total, ۳۰ Wistar rats were divided into three groups and treated (except the normal control) with lead acetate in drinking water (۱,۰۰۰ mg/l) for five weeks. The control rats and negative control rats received saline intraperitoneally, and the third group received intraperitoneal injections of selenium nanoparticles (۰.۵ mg/kg).
Results: The lead-treated group showed a significant increase in blood urea nitrogen, serum creatinine, serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), and malondialdehyde levels (P < ۰.۰۱). The lead-intoxicated rats treated with selenium nanoparticles showed a significant decrease in serum AST and ALT compared to the untreated negative controls (P < ۰.۵). The histopathological examination of liver and kidney tissues indicated lead-induced injuries (e.g., necrotic cells in liver and kidneys). The selenium-treated group showed reduced histopathological signs of lead-induced injuries. Lipid peroxidation levels were also lower in the selenium-treated rats compared to the negative controls (P < ۰.۰۵).
Conclusion: This experimental study confirmed the protective effects of selenium nanoparticles in the rats exposed to chronic lead-induced toxicity. However, further experiments are required to evaluate the possible side-effects and complications.
کلمات کلیدی: Lead acetate, selenium nanoparticles, liver, kidney, Toxicity
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1600917/