Mansour Karajibani - Health Promotion Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Farzaneh Montazerifar - Pregnancy Health Research Center, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Hadi Eslahi - Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Sazin Yarmand - Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Mahdiyyeh Miri - Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
Mehrdad Naghizadeh - Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Background: Abnormality in metabolism of lipids and hyperlipidemia is a risk factor for atherosclerosis which is the major cause of cardiovascular diseases (CVDs). Several herbal drugs are used for the treatment of dyslipidemia. The present study investigates the effects of hydroalcoholic extracts of Senna extract on serum lipid profile among hyperlipidemic rats. Methods: Forty eight male Wistar rats were randomly divided into ۶ groups of ۸ animals, including group ۱) normal pellet diet (control), group ۲) high fat diet (HFD), group, ۳) HFD with ۱۰۰ mg/kg Senna extract treatment, group ۴) HFD with ۲۰۰ mg/kg Senna extract treatment, group ۵) ۱۰۰ mg/kg pure Senna extract, and group ۶) ۲۰۰ mg/kg pure Senna extract. All the dietary regimens and Senna extract treatments were continued for ۳۰ days. At the end of the experiment, blood samples collected from heart of rats and the lipid profile levels were measured. Results: The results indicated that short-term treatment by hydroalcoholic of Senna extract produced a significant reduction in the level of cholesterol, triglyceride, and LDL-C (P < ۰.۰۵), as well as an increase in HDL-C. The body weight in the HFD group was significantly higher than the other groups (P < ۰.۰۵). Conclusion: Prescription of hydroalcoholic extracts of Senna is effective in the treatment of hyperlipidemia, and can inhibit the weight gain induced by HFD in rats. Some of these effects could be attributed to antioxidants activities, biological and pharmaceutical properties and other protective properties of the Senna extract requiring further investigations

Senna extract, Hyperlipidemia, Rat