Maryam Pourshab - University of Mazandaran, Babolsar, Iran
Seyede Sara Khalili - Mazandaran University of Science and Technology
Mohaddeseh Kariminasab - University of Mazandaran, Babolsar, Iran
Sakineh Asghari - Department of Organic Chemistry, Faculty of Chemistry,University of Mazandaran, Babolsar, Iran

An efficient synthesis of hydrazono-۴-thiazolidinones is reported using three-component reactions of various ketone derivatives (carbonyl compound), thiosemicarbazide and dialkyl acetylenedicarboxylate (or maleimide) in presence of nano silica-bonded aminoethylpiperazine (SB-APP) as heterogeneous catalyst. The reaction catalyst was recycled and reused without significant loss of catalytic efficiency. This eco-safe protocol offers several advantages such as a short reaction times, mild reaction conditions, excellent yield and green procedure.

nano silica-bonded aminoethylpiperazine (SB-APP), heterogeneous catalyst, hydrazono-۴-thiazolidinones .