A Root Cause Analysis of Haemolysis Encountered in Leuco-filtration of Stored Packed Red Cells Units
عنوان مقاله: A Root Cause Analysis of Haemolysis Encountered in Leuco-filtration of Stored Packed Red Cells Units
شناسه ملی مقاله: JR_JIML-9-1_006
منتشر شده در در سال 1400
شناسه ملی مقاله: JR_JIML-9-1_006
منتشر شده در در سال 1400
مشخصات نویسندگان مقاله:
امیتا ر - Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
اریا اب - Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
ساتیابهاما اس - Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
دبسیش گوپتا - Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
خلاصه مقاله:
امیتا ر - Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
اریا اب - Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
ساتیابهاما اس - Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
دبسیش گوپتا - Department of Transfusion Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India
Background and Aims: Leukoreduction of blood components has reduced the incidence of transfusion-associated adverse events. Leucofiltration is the most effective method of leukoreduction. We encountered haemolysis in a series of leucofiltered units. This stressed our precious inventory, added to financial loss, increased our turn-around time to issue leucofiltered blood units, and placed doubts on the safety of our leucofiltered products. A systematic root cause analysis was done to identify the reason for haemolysis.
Materials and Methods: A total of ۶۹ units were leucofiltered during the study period, of which ۱۳ units showed lysis following filtration.
Results: This study warranted a review of our existing leucofiltration standard operating procedures to keep strict adherence to manufacturer instructions to ensure quality in the end product.
Conclusions: Among the leucofiltered units showing hemolysis, ۶۲% were due to higher temperature, ۲۳% due to increased time for filtration, and ۱۵% due to increased holding time of red cell units.
کلمات کلیدی: Haemolysis, Leucofiltration, Packed red cells, Root cause analysis, Storage, Temperature
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1608206/