مهسا دکتر ارسطویی مرندی - Department of Anatomy and Cell Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
مریم یادگاری - Department of Anatomy and Cell Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
عباس شاهدی - Department of Anatomy and Cell Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
مجید پورانتظاری - Department of Anatomy and Cell Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
مرتضی انوری - Department of Anatomy and Cell Biology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
آزاده شاهرخی رائینی - Department of Physiology Nursing Biomedical Research Center, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
هنگامه درتاج - Department of Tissue Engineering and Applied Cell Science, Shiraz University of Applied Medical Science and Technologies, Shiraz, Iran

Background and Aims: This study aimed to observe the effect of Icariin on histomorphometric changes of testis and prostate induced by Acrylamide. Materials and Methods: Male mice were divided into four groups (n=۸): A is the control group and does not get any treatment, B is the sham group and only received drinking water. C group received Acrylamide ۱۰ mg/kg. D group received Acrylamide ۱۵ mg/kg+۱.۵ mg/kg of Icariin. Histological changes in testis and prostate were examined using stereological methods. Results: Results showed decreases in testis weight of the group treated by (p≤۰.۰۱) and the group cured by Acrylamide +Icariin group (p≤۰.۰۵). The total volume of testis showed a reduction in the Acrylamide  group compared to other groups (p≤۰.۰۵). The total number of spermatogonia and spermatocyte cells in the Acrylamide group showed a decrease in comparison with the other groups (p≤۰.۰۵). The total number of spermatid cells in the Acrylamide group indicated a significant reduction in comparison with the control and sham group (p≤۰.۰۵). The total number of sertoli cells in the Acrylamide group showed a reduction when the number of leydig cells in the Acrylamide group showed a significant decrease in comparison with the control, sham, and Acrylamide+Icariin groups (p≤۰.۰۵). The mean Johnsen score was decreased in the Acrylamide treated group compared to control, sham, and Acrylamide+Icariin groups (p≤۰.۰۵). Testosterone concentration in the Acrylamide group showed a reduction in comparison with control, sham, and Acrylamide+Icariin groups (p≤۰.۰۵). Conclusion: Results demonstrated that Acrylamide altered the structure of the testis, prostate gland, and spermatogenesis stage, and Icariin treatment improved these histopathological changes.

Icariin, Acrylamide, Testis, Prostate, Stereology, Mice, آکریل امید, ایکارین, بیضه, پروستات, استریولوژی, موش.