Saba Gharibi - ۱. Genetic Engineering and Genome Editing Laboratory, Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ۲. Department of Genetics, Faculty of Medicine, International Campus
Bahram Moghimi - ۳. Department of Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammadtaher Tahoori - ۴. Department of immunology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Mohammadbagher Mahmoudi - ۵. Department of Genetic Research, ROJE Technologies, Yazd, Iran
Ensieh Shahvazian - ۵. Department of Genetic Research, ROJE Technologies, Yazd, Iran
Ehsan Farashahi Yazd - Genetic Engineering and Genome Editing Laboratory, Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Multiple sclerosis (MS) is the most common autoimmune inflammatory demyelinating disease that affects the brain and spinal cord. Dysregulation or mutation of miRNA genes have been linked to the pathogenesis of MS. The miRNAs are short, ۲۰-۲۲ nucleotide long, single-stranded regulatory and non-protein coding RNAs that modulate the expression of multiple target genes. Among miRNAs, miR-۲۲۳ has been reported to play a critical role in MS. This review concentrates on the emerging role of miR-۲۲۳ in inflammatory responses and specifically discusses how alterations in miR-۲۲۳ expression are associated with the development of MS. This review also suggests that miR-۲۲۳ can be used as a biomarker for diagnosis of MS and discovering novel therapeutics for MS treatment.

Inflammation, Marker, MicroRNA, miR-۲۲۳, Multiple sclerosis, ---