Curcumin ameliorates chronic Toxoplasma gondii infection-induced affective disorders through modulation of proinflammatory cytokines and oxidative stress

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-26-4_012

تاریخ نمایه سازی: 9 اسفند 1401

Abstract:

Objective(s): Long-term infection with Toxoplasma gondii is associated with affective disorders (i.e., anxiety and depression) in adults. We aimed to explore the effects of curcumin (CR) on anxiety- and depressive-like behaviors in mice infected with T. gondii. Materials and Methods: Animals were studied in five groups: Control, Model, Model + CR۲۰, ۴۰, and ۸۰ (with IP injection of ۲۰, ۴۰, and ۸۰ mg/kg CR).  T. gondii infection was prolonged for four weeks. The animals were then treated with CR or vehicle for two weeks and evaluated by behavioral tests at the end of the study. Hippocampal levels of oxidative stress biomarkers (superoxide dismutase; SOD, glutathione; GSH, and malondialdehyde; MDA) and gene expression and protein levels of hippocampal proinflammatory mediators (interleukin-۱β; IL-۱β, IL-۶, IL-۱۸, and tumor necrosis factor- α; TNF-α) were determined. Results: Behavioral tests confirmed that long-term infection with T. gondii led to anxiety- and depressive-like behaviors. Antidepressant effects of CR were linked to modulation of oxidative stress and cytokine network in the hippocampal region of infected mice. These results showed that CR reduced anxiety and depression symptoms via regulation of oxidative stress and proinflammatory cytokines in the hippocampus of T. gondii-infected mice. Conclusion: Therefore, CR can be used as a potential antidepressant agent against T. gondii-induced affective disorders.

Authors

Fatemeh Moradi

School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Nasrin Dashti

Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

Amirali Farahvash

Özel Medipark Tıp Merkezi, Ankara, Turkey

Farinaz Baghaei Naeini

Science and Research branch, Islamic Azad University, Tehran, Iran

Mitra Zarebavani

Department of Clinical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

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