Elizabeth Guzmán Hernández - Medical Surgeon Career, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, ۵۴۰۹۰, Mexico
David Segura Cobos - Medical Surgeon Career, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, ۵۴۰۹۰, Mexico
Maria del Rosario Gonzalez Valle - Histology Laboratory, Morphology and Function Unit, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, ۵۴۰۹۰, Mexico
José del Carmen Benítez Flores - Histology Laboratory, Morphology and Function Unit, Faculty of Superior Studies Iztacala, National Autonomous University of Mexico, Tlalnepantla, State of Mexico, ۵۴۰۹۰, Mexico
Rubén San Miguel Chávez - Phytochemistry Area, Postgraduate Degree in Botany, Campus Montecillo, Postgraduate College, Km. ۳۶.۵ México-Texcoco Road, Montecillo, Texcoco, State of Mexico, C.P. ۵۶۲۳۰, Mexico
Leonardo Mondragón - Department of Pharmacology, National Institute of Cardiology Ignacio Chávez, Mexico City, C.P. ۰۴۵۱۰, Mexico
Gil Alfonso Magos Guerrero - Department of Pharmacology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacán, Mexico City, C.P. ۰۴۵۱۰, Mexico
Pedro Lopez-Sanchez - Postgraduate Studies and Research Section, Higher School of Medicine, National Polytechnic Institute, Mexico City, ۱۱۳۴۰, Mexico

Objective(s): Metabolic syndrome is associated with the development of chronic kidney disease. Bursera simaruba “chaca” is a medicinal plant used in Mexico for hypertension and empirical therapy.  In this study, were examined the effects of ethanol extract of B. simaruba on metabolic syndrome.Materials and Methods: For induction of metabolic syndrome, ۲۰% fructose was used, and it was administered in the water and food to male Wistar rats for ۱۲ weeks, after administering ethanol extract of B. simaruba intragastrically (۱۰۰ and ۲۰۰ mg/kg/day) for ۶ weeks, blood pressure was determined. In plasma, glucose, cholesterol, triglycerides, angiotensin II, oxide nitric, and angiotensin ۱-۷ were quantified. In the kidney was performed histological study and the activity of anti-oxidant enzymes was quantified. Results: Rats with metabolic syndrome developed obesity, arterial hypertension, dyslipidemia, and kidney damage characterized by proliferative glomerulonephritis, necrosis, and reduced activity of anti-oxidant enzymes. These alterations were significantly ameliorated by ethanol extract of B. simaruba.Conclusion: The ethanolic extract of B. simaruba showed antidyslipidemic, antihypertensive, anti-oxidant, and renoprotective effects.

blood pressure, Bursera simaruba, Hyperlipidemia, Kidney Failure, metabolic syndrome, Obesity, Oxidative stress