Hedayat Jafari - Associated Professor, Traditional and Complementary Medicine Research Center, Addiction Institute,Mazandaran University of Medical Sciences, Sari, Iran.
Javad Ghaffari - Infectious Disease Research Center with Focus on Nosocomial Infection, Department of Pediatrics,Mazandaran University of Medical Sciences, Sari, Iran.
Pooneh Dadashian - M.Sc. Student of Intensive Care Nursing, Student Research Committee of Mazandaran University of MedicalSciences, Sari, Iran

Background: diabetic ketoacidosis (DKA) is not the most common acutecomplication of type ۱ diabetes in children and adolescents, but cerebral edema is theleading cause of death in children with DKA.Objectives: The purpose of this study was to systematically review the literature todescribe the Predisposing factors of cerebral edema in Pediatric DiabeticKetoacidosis.Methods: sex international databases of Wiley, Medline, Scopus, web of science,ProQuest, and Cochrane Library s, and three Persian databases, including SID,Magiran, and Iranmedex were searched for relevant studies. Then, literature withinclusion criteria related to the objectives of this study were reviewed.Results: These studies have identified several risk factors for cerebral edema, some ofwhich are related to the severity of the disease at admission and some of which arerelated to treatment.Conclusion: Preventing DKA is the only reliable way to prevent cerebral edema untilthe causes of this life-threatening complication are fully understood.

Cerebral edema; Brain Edema; Pediatric; Diabetic Ketoacidosis