Afsane Bahrami - a) Assistant Professor, Clinical Research Development Unit, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran b) Lecturer, Clinical Research Development Unit of Akbar Hospital, Mashhad University of Medical Sciences,
Masoumeh Askari - a) Lecturer, Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran b) Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Zahra Rajabi - Lecturer, Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
Zahra Sadat Hoseini - Graduated, Department of Psychology, University of Birjand, Birjand, Iran
Gordon Ferns - Professor, Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN۱ ۹PH, UK

Background & aim: Restless leg syndrome (RLS) is a frequent sensory dyskinesia disorder of the nervous system and a cause of disability in several aspects. This study aimed to determine the relationship between RLS and mood complications, menstrual patterns, and its associated symptoms among young women.Methods: This cross-sectional study was undertaken on ۱۱۸ female university students in Birjand, Iran, from December ۲۰۱۹ to January ۲۰۲۰ using a multistage cluster sampling method. The degree of RLS was assessed using the International RLS Severity Scale. The severity of PMS was characterized via the Premenstrual Syndrome Screening Tool (PSST). Neuropsychological performance of participants was evaluated. Data analysis was performed by SPSS software (version ۱۶.۰).Results: Of ۱۱۸ participants, ۲۹.۷%, ۳۲.۲%, ۲۷.۹%, and ۱۰.۲% of them were not affected by RLS or suffered from mild, moderate, or severe types of RLS, respectively. The subjects with RLS had a significantly lower duration of their menstruation cycle and higher PSST scores compared to those without it. Subjects with different severities of RLS scored higher for the severity of depression, anxiety, stress, insomnia, and sleepiness than normal women (P<۰.۰۱). The RLS score was a significant factor related to the scores for cognitive abilities (β=-۰.۳۳; P=۰.۰۲۲), depression (β=۰.۳۲; P=۰.۰۰۱), anxiety (β=۰.۲۴; P=۰.۰۰۳), stress (β=۰.۴۴; P<۰.۰۰۱), quality of life (β=-۰.۲۳; P<۰.۰۰۱), insomnia (β=۰.۲۱; P=۰.۰۰۱), sleepiness (β=۰.۱۵; P=۰.۰۱۴) and PSST (β=۰.۲۸; P=۰.۰۱۹).Conclusion: In the absence of health management, RLS is potentially associated with depression, anxiety, sleep disruption, cognitive impairment, decreased quality of life, and menstrual problems.

Restless leg syndrome, stress, Menstruation, insomnia, Dysmenorrhea