Behnam Doudkanlouy Milan - MS Student, Department of Materials Engineering, Faculty of Engineering, Urmia University, Urmia, West Azerbaijan, Iran
Hurieh Mohammadzadeh - Assistant Professor, Department of Materials Engineering, Faculty of Engineering, Urmia University, Urmia, West Azerbaijan, Iran
Robabeh Jafari - Assistant Professor, Department of Materials Engineering, Faculty of Engineering, Urmia University, Urmia, West Azerbaijan, Iran
Mohammad Soltani - PhD Candidate, Department of Materials Engineering, Faculty of Engineering, Tarbiat Modares Universirty, Tehran, Tehran, Iran

In recent years, application of Hydroxyapatite (HA) as the coating on metal substrates for biological stabilization of implants, stimulation of bone growth around the implant, and optimization of recovery time has attracted the attention of many researchers around the world. In this regard, the current study presented a review of HA and its composite coatings for tissue engineering applications. HA is one of the bioceramics that has been an interesting subject of research in recent years owing to its in-vitro bioactivity, osteoinduction, and osteoconduction properties. According to the previous reports, coated implants were performed successfully to achieve high corrosion resistance, bone growth and regeneration, and reduction of corrosion current density. The current research presented a review of the previous research works on the coating mechanism, physico-mechanical, in-vitro bioactivity, and biocompatibility properties of HA and its composite coatings on substrates. The obtained results revealed that HA and its composites had a synergistic effect on the metal substrates in terms of improving corrosion resistance, providing biocompatibility, direct bonding to tissue, accelerating treatment, and reducing costs imposed on the health care sector.

Hydroxyapatite, coating, metal substrates, Osteoinduction, Tissue engineering