Seyed Kazem Mirinezhad - Liver and Gastrointestinal Disease Research Center Tabriz University of medical sciences Tabriz, Iran

Background: The reproductive patterns of women have long-term implications for women’s health ,), yet only a few studies have addressed the protective effect of breastfeeding in breast cancer and childbirth affect lifespan (۴), however, the impact number of childbirth on colon cancer patient survival is unclear. Colorectal cancer is the third most common non-skin malignancy in women, after breast and lung cancer (۵). The aim of the present study was to investigate the relationship between the number of childbirth and survival in colorectal cancer. Methods: From February ۲۰۰۷ to February ۲۰۱۷, ۲۳۳ female patients with colorectal cancer (CRC) were enrolled and their data including the number of childbirth and clinic pathological characteristics of the tumor were retrospectively analyzed. Patients were divided into two groups based on the number of childbirth, (<۵ and ≥۵). Data were analyzed using the Kaplan-Meier method and log-rank test, p value < ۰.۰۵ was set as statistically significant. The survival of CRC patients was compared based on the number of childbirth. Results: Of the ۲۳۳ patients analyzed, ۱۰۰ % were females. The mean age was ۵۷.۳ ± ۱۳.۶, ranging from ۲۰ to ۸۸ years. The five-year survival rate among patients the number of childbirth <۵ was ۲۷%, compared to ۳۳% for the number of childbirth ≥۵ (p=۰.۶). )Figure ۱(.The five-year survival rate of the two groups was different, but it was not statistically significant. Conclusions: Among patients with colorectal cancer, the number of childbirth did not have a significant effect on prognosis.

number of childbirth, survival. Colorectal cancer