Samaneh Salarvand - Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Farzaneh Bagheri - Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Mahsa Gholizadeh - Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Sima Sharifi - Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Pooneh Panahi - Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Ebrahim Esmati - Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Marzieh Lashkari - Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Amirmohsen Jalaeefar - Department of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Mohammad Shirkhoda - Department of Oncosurgery, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Reza Shahsiah - Department of Clinical and Anatomical Pathology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Reza Ghalehtaki - Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Background & Objective: Iran is located in the esophageal cancer geographical belt. As multiple genetic alterations are responsible for the molecular pathogenesis of esophageal squamous cell cancer (ESCC), the role and frequency of HER۲ expression, MMR deficiency, and PI۳KCA mutation are not well defined.Methods: We carried out HER۲/neu expression, dMMR/MSI high, and PI۳KCA mutation analysis in specimens of patients with ESCC. We accessed archival tissue blocks related to specimens of ۶۸ ESCC cases at the time of surgery following neoadjuvant chemoradiation. These patients underwent surgery during ۲۰۱۳-۲۰۱۸ at the Cancer Institute of Iran affiliated with the Tehran University of Medical Sciences in Tehran.Results: None of the patients showed HER۲ expression, dMMR/MSI high, or PI۳K mutations.Conclusion: dMMR/MSI-H and PI۳KCA mutation and HER۲ expression may not be reliable andfrequent targets for systemic therapy in patients with esophageal SCC.

DNA Mismatch Repair, Esophageal Neoplasms, HER Family Receptor, Kinase, Squamous cell carcinoma