Reza Zare - Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamidreza Abdolsamadi - Dental Research Center, Department of Oral Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Sara Soleimani Asl - Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran.
Shahrbanoo Radi - Department of Oral Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
Hossein Bahrami - General Dentist, Private Practice, Hamadan, Iran.
Shokoofeh Jamshidi - Department of Oral and Maxillofacial Pathology, School of Dentistry, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: The role of the basic fibroblast growth factor (bFGF) has well known in the angiogenesis and ulcer healing. In this study, we aimed to evaluate the effects of bFGF on tissue repair in a rat oral mucosal wound. Methods: Musosal wound induced on the lip mucosa of rats and bFGF was injected along the edge of the mucosal defect immediately after surgery. The tissues were collected on days ۳, ۷ and ۱۴ after the wound induction. The micro vessel density (MVD) and CD۳۴ expression were done by histochemical studies. Results: The bFGF significantly accelerated granulation tissue formation and MVD was increased three days after ulcer induction but decreased ۱۴ days after surgery. The MVD was significantly higher in the bFGF-treated group. The wound area was decreased in all groups time-dependently and a statistically significant difference (p value?) was observed between the bFGF-treated group and untreated group. The wound area was smaller in the bFGF-treated group compared to the untreated group. Conclusions: Our data demonstrated that bFGF can accelerated and facilitated wound healing.

bFGF, Healing, Angiogenesis, Wound, Micro Vessel Density.