Rajesh Das - Department of Chemistry, University of North Bengal, Bengal, India
Deboshmita Mukherjee - Department of Chemistry, University of North Bengal, Bengal, India
Sahin Reja - Department of Chemistry, University of North Bengal, Bengal, India
Kaushik Sarkar - Department of Chemistry, University of North Bengal, Bengal, India
Ambica Kejriwal - Department of Chemistry, University of North Bengal, Bengal, India

The N۳ tridentate ligand N,N-dimethyl-N-(۱-pyridinylmethylidene) propane-۱,۳- diamine (DPMPD) and its copper complex (CDPMPD) were synthesized of which metal complex is found  in green colour  powdered form. The associated spectroscopic techniques were used to characterize both ligand and the metal complex. Powder XRD method was utilized using the Scherrer formula to accomplish the grain size of the metal complex. It was found that the experimental results of the powdered complex were quite similar to that of the reference material with JCPDS ID ۰۰- ۰۲۴-۱۹۷۷. In vitro anticancer activity shows that the metal complex exhibits a moderate cytotoxic effect on Hep-G۲ cell line. This cytotoxic phenomenon is well supported by a molecular docking study using target topoisomerase II crystal structure (PDB id ۴FM۹). The HOMO- LUMO energy gap, predicted from the DFT study, signifies that the complex is susceptible to chemically reactive.

DPMPD, CDMPD, anticancer activity, DFT, Docking