Susan Darroudi - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Payam Sharifan - Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahsa Rastegar Moghaddam Poorbagher - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
Maryam Mohamadi Bajgiran - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Sara Saffar Soflaei - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamideh Ghazizadeh - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
habibollah esmaily - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Niloofar Shabani - Department of Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran
Ramin Sadeghi - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Vahid Reza Dabbagh Kakhki - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Ebrahimi Dabbagh - Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
Mohammad Amin Mohammadi - Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
Mohammad Amin Mohammadi - Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
sara Moazedi - Department of Nutrition Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran
Mahdi Rafiee - Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
reza Assaran Darban - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran ۵. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Gordon A. Ferns - Department of Medical Education, Brighton and Sussex Medical School, Falmer, Brighton, UK.
Mohsen Mohebati - Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
majid Ghayour - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

Introduction: Metabolic syndrome (MetS) is comprised of a clustering of various cardiovascular risk factors that can also affect bone health. We aimed the associations between MetS and bone mineral density (BMD) and trabecular bone score (TBS) in subjects with abdominal adiposity.Methods: Individuals with body mass index less than ۲۵ kg/m۲ were enrolled from the SUVINA study and allocated into two groups according criteria of IDF for metabolic syndrome. TBS T-score and Z/T score of fore skeletal region were measured using dual-energy X-ray absorptiometry (DXA). SPSS software was used for statistical analysis and p value ۰<۰.۰۵ was considered significant.Results: DXA measurements were made in ۲۰۱ participants, of whom ۷۵ had MetS and ۱۲۶ did not. Scores related to the neck of femur and total femur, radius Z-score and TBST-score were lower in subjects with MetS (all P<۰.۰۵). Subjects with FBG≥۱۰۰ had lower TBST-score (p < ۰.۰۵). SBP≥۱۳۰ and DBP≥۸۵ in subjects, led to the lower TBST-score, and lumbar T-score (both P < ۰.۰۵). Subjects with (LDL-C≥۱۶۰ mg/dl) had lower TBST-score, neck of femur Z score, and total femur T/Z scores (all P < ۰.۰۵). TBST-score and scores related to neck of femur, and total femur were lower in participants with serum cholesterol≥۲۰۰ mg/dl (P < ۰.۰۵).Conclusion: MetS is negatively associated with TBS and BMD scores. Higher levels of LDL-C and cholesterol were the most associated factors related to TBST-score decrease. The neck of femur was the most vulnerable skeletal against the MetS components increment.

Trabecular bone score, Bone mineral density, metabolic syndrome, Serum lipids