Payam Sharifan - Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mahdi Rafiee - Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Niloofar Shabani - Department of Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran, Iran
Sara Saffar Soflaei - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran.
Susan Darroudi - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Mahnaz Amini - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Mohamadi Bajgiran - Iranian UNESCO center of excellence for human nutrition, Mashhad University of Medical
Zahra Ghazizadeh - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
shima Dehghani - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
zahra Aghaee - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
Mahshid Farsi - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
Melika Malek - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
Niloofar Safari - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
Hamideh Ghazizadeh - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
Reza Assaran Darban - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
Mahsa Rastegar Moghaddam Poorbagher - Department of Biology, Mashhad Branch, Islamic Azad university, Mashhad, Iran
Gordon A. Ferns - Department of Medical Education, Brighton and Sussex Medical School, Falmer, Brighton, UK.
Habibollah Esmaily - Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Majid Ghayour - International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

Introduction: Depression, anxiety, and stress have been shown to be associated with quality of life and sleep quality. This association did not examine separately in men and women. In the present study, we aim to examine the association between depression, anxiety and stress with RLS, Epworth, insomnia, apnea, PSIQ and QoL by gender in Mashhad-study data.Methods: A total of ۲۸۹ individuals (۱۴۳ male and ۱۴۶ female) aged ۳۰-۵۰ years old who completed the SUVINA study. They completed the Epworth sleepiness scale (ESS), Pittsburg sleep quality index (PSQI) and quality of life (QoL). For statistical analysis, SPSS software was used for data analysis and p value ۰<۰.۰۵ was considered significant.Results: Depression scores were correlated with higher scores for RLS, ESS, insomnia, and PSQI in men but inversely related to QoL (P < ۰.۰۵). RLS and PSQI was positively correlated with anxiety in women, and subjects without anxiety had lower mean of RLS and PSQI scores than the other anxiety groups (P < ۰.۰۵ for both). QoL was conversely associated with anxiety in women. Stress was related with higher scores of RLS, ESS, insomnia and PSQI in men (all P <۰.۰۵).Conclusion: OlderAlthough scores for depression, anxiety and stress were higher in women compared to men, the association of depression, anxiety and stress with RLS, quality of life and sleep quality varies between genders and unlike our expectation these disorders were more highly correlated with RLS, QoL and sleep quality in men.

Depression, Anxiety, stress, Quality of life, Sleep Disorders, Restless legs syndrome