Sule Yildirim Kopuk - Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.
Zeynep Ece Utkan Korun - Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.
Aysen Yuceturk - Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.
Ozge Karaosmanoglu - Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.
Caglar Yazicioglu - Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey.
Bulent Tiras - Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey. Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.
Yigit Cakiroglu - Acibadem Maslak Hospital, Assisted Reproductive Technologies Unit, Istanbul, Turkey. Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Background: With the introduction of the dual triggering-gonadotropin-releasing hormone (GnRH) analog and recombinant human chorionic gonadotropin (hCG) combination, women with a history of low mature oocyte proportion and empty follicle syndrome were shown to benefit from the dual trigger. Objective: To investigate whether dual triggering of oocyte maturation with a GnRH agonist (GnRHa) combined with hCG can affect the euploidy rate and improve in vitro fertilization outcomes for normoresponder women. Materials and Methods: In this cross-sectional study, ۴۹۴ women who underwent controlled ovarian stimulation with hCG (n = ۲۷۴) or dual triggering (hCG+GnRHa, n = ۲۲۰) at Acibadem Maslak hospital, Assisted Reproductive Unit, from January ۲۰۱۹-۲۰۲۲ were enrolled in this study. Preimplantation genetic testing for aneuploidy was performed on all participants. Results: Both groups had similar baseline and clinical characteristics. Of the ۸۸۱ embryos biopsied, ۳۱۲ (۳۵.۴%) were reported as euploid in the hCG trigger group; in the dual trigger group, ۱۸۶ (۲۹.۸%) of ۶۲۳ screening embryos were reported as euploid. The hCG group had a higher euploidy rate per biopsied embryo, although the difference was not statistically significant (۳۱.۴ ± ۲۶.۵ vs. ۲۶.۵ ± ۳۳.۳, p > ۰.۰۵). Conclusion: In normoresponders, adding GnRHa for final follicular maturation to hCG did not improve the euploidy rate.

Gonadotropin-releasing hormone, Chorionic gonadotropin, Preimplantation screening, Aneuploidy., هورمون آزاد­کننده گنادوتروپین, گنادوتروپین کوریونی, غربالگری قبل از لانه­گزینی, آنیوپلوئیدی.