Fatemeh Mortazavi Moghadam - Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran; Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, MA, ۰۲۱۳۹, USA
Mohammadreza Bigdeli - Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran
Su Ryon Shin - Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham and Women’s Hospital, Cambridge, MA, ۰۲۱۳۹, USA

Cortisol plays an important part in physiological procedures. Observing cortisol concentration as a stress indicator demonstrates the physiological mode for the diagnosis goal. The mechanism of the presented nano biosensor is LSPR and is performed based on the nucleic acid aptamer functionalized with gold nanoparticles which have specific interaction with cortisol. The interaction of aptamer particular measurement of cortisol was accomplished over the concentration from ۰.۰۵ -۰.۲ μg·mL-۱ within ۲۰ minutes. The detection limit is estimated to be ۰.۰۲ μg.mL-۱.

Aptamer, Silver Nanoparticles, Nanobiosensor, Cortisol