Mesenchymal stem cell therapy in amyotrophic lateral sclerosis (ALS) patients: A comprehensive review of disease information and future perspectives

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-26-8_003

تاریخ نمایه سازی: 3 تیر 1402

Abstract:

Amyotrophic lateral sclerosis (ALS) is a rare deadly progressive neurological disease that primarily affects the upper and lower motor neurons with an annual incidence rate of ۰.۶ to ۳.۸ per ۱۰۰,۰۰۰ people. Weakening and gradual atrophy of the voluntary muscles are the first signs of the disease onset affecting all aspects of patients’ lives, including eating, speaking, moving, and even breathing. Only ۵-۱۰% of patients have a familial type of the disease and show an autosomal dominant pattern, but the cause of the disease is unknown in the remaining ۹۰% of patients (Sporadic ALS). However, in both types of disease, the patient’s survival is ۲ to ۵ years from the disease onset. Some clinical and molecular biomarkers, Magnetic Resonance Imaging (MRI), blood or urine test, muscle biopsy, and genetic testing are complementary methods for disease diagnosis. Unfortunately, with the exception of Riluzole, the only medically approved drug for the management of this disease, there is still no definitive cure for it. In this regard, the use of Mesenchymal Stem Cells (MSCs) for the treatment or management of the disease has been common in preclinical and clinical studies for many years. MSCs are multipotent cells having immunoregulatory, anti-inflammatory, and differentiation ability that makes them a good candidate for this purpose. This review article aims to discuss multiple aspects of ALS disease and focus on MSCs’ role in disease management based on performed clinical trials.

Authors

Shahrzad Najafi

Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Parizad Najafi

Department of Biology, Mashhad Branch, Islamic Azad University, mashhad, Iran

Najmeh Kaffash Farkhad

Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ghazal Hosseini Torshizi

Department of Biology, Mashhad Branch, Islamic Azad University, mashhad, Iran

Reza Assaran Darban

Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran

Amir Reza Boroumand

Neuroscience Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Sajad Sahab-Negah

Neuroscience Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Ali Khodadoust

Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Jalil Tavakol Afshari

Immunology Research Center, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

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