Roshan Topno - Department of Epidemiology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Krishna Pandey - Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Banke Singh - Department of Pediatrics, Anugrah Narayan Magadh Memorial Medical College Hospital, Gaya- ۸۲۳۰۰۱, India
Manas Dikhit - Department of Bioinformatics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Ashish Kumar - Department of Biochemistry, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Maneesh Kumar - Department of Virology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Ganesh Sahoo - Department of Bioinformatics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Vidya Nand Rabidas - Department of Clinical Medicine, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Niyamat Siddiqui - Department of Bio-Statistics, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Wakil Paswan - Department of Pediatrics, Anugrah Narayan Magadh Memorial Medical College Hospital, Gaya- ۸۲۳۰۰۱, India
Arjun Lal - Department of Microbiology, Anugrah Narayan Magadh Memorial Medical College Hospital, Gaya-۸۲۳۰۰۱, India
Diwakar Dinesh - Department of Vector Biology and Control, ICMR- Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India
Pradeep Das - Department of Molecular Biology, ICMR-Rajendra Memorial Research Institute of Medical Sciences, Agamkuan, Patna-۸۰۰۰۰۷, India

Background: From Gaya and adjoining regions, the trend in patients admitted with acute neurological illness was investigated. Illnesses were identified as sudden outbreaks of Japanese virus encephalitis (JE), Herpes simplex virus encephalitis (HSV-۱&۲), and other acute encephalitis syndrome (AES). Objective: In the current study, an investigation was carried out to assess potential infectious pathogens in patients aged ۱۶ years or younger who were admitted to Anugrah Narayan Magadh Memorial Medical College Hospital, Gaya, with encephalitis-like symptoms. Methods: Cross-epidemiological, serological, and molecular biological studies were performed on samples collected from ۷۱ patients below ۱۶ years of age. Patients’ clinical histories, i.e. fever, socio-demographic characteristics, and other clinical data, were extracted from patient files. Results: The results showed confirmed AES cases, including ۴۹.۳۰% JE and ۷.۰۴% HSV positive patients. A higher case-fatality rate of ۴۰% in JE and ۴۰% HSV cases below ۷ years of age were observed during treatment would become an unavoidable concern. The epidemical sex ratio was observed to be higher in girls than in boys (۱.۲۶:۱). Conclusion: The results suggested that JE virus was found to be a main causative risk factor responsible for disease transmission in the outbreak area.

Acute Encephalitis Syndrome, Enzyme-Linked Immunosorbent Assay (ELISA), Herpes Simplex Virus (HSV), Japanese Encephalitis, Outbreak