Esmaeil Saber - FACTULY OF VETERINARY MEDICEN, TABRIZ UNIVERSITY. TABRIZ-IRAN.
Fahime Bagheri Amiri - FACTULY OF VETERINARY MEDICEN, TABRIZ UNIVERSITY. TABRIZ-IRAN.
Ebrahim Bagheri Amiri - PHARMACY GRADUATE OF TEHRAN MEDICAL UNIVERSITY.TEHRAN- IRAN.
Mohammad Majidi - PHARMACY GRADUATE OF TABRIZ MEDICAL UNIVERSITY. TABRIZ-IRAN

Probiotics are defined as living microorganisms that confer a health benefit on the host and they have been mostly studied in the prevention and treatment of gastrointestinal disorders. The purpose of the present study was to review the immunomodulatory properties of yogurt containing probiotic strains. Literature survey reveals beneficial potentials of yogurt in various ways like lowering cholesterol levels, improving immune system, balancing gut micro flora and preventing constipation, diarrhea and bloating, preventing fungal infection and improving digestibility of food constituents and improves immune response and anticarcinogenic activity. Role of yogurt as probiotic in improvement of immunity, production of cytokines and on immune function has been evaluated. Taken together, all the beneficial immunological potentials of yogurt in probiotic immunotherapy could be of clinical significance. Probiotic immunotherapy using yogurt could be an emerging field of disease management through the diet. However, molecular mechanisms leading to yogurt- induced immunomodulation are poorly understood. Thus, we strongly recommend that yogurt could be further developed as a possible potential universal antineoplastic agent for multitargeted therapy, which is not only cost effective but also easily available and clinically safe for human trials.

Probiotic; Anticancer; Immunomodulation; Yogurt