Reza Mohtashami - Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Mehdi Raei - Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Mahdi Bagheri - Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Alireza Shahriary - Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
Hassan Goodarzi - Emergency department , Trauma Research Center , Baqiyatallah University of Medical Sciences, Tehran, Iran
Mostafa Soodmand - School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran
Milad Asghardoust Rezaei - Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran

Background: One of the recommended treatment methods for covid-۱۹ is herbal treatments, which, if used, can be used as an effective preventive or supportive treatment in the treatment plan of patients with covid-۱۹. PHR۱۶۰ spray is combination of cineole, menthol, safran, safranal , crocin that each of these substances effects on respiratory diseases alone.Aim: Investigating the effectiveness of PHR-۱۶۰ spray, in the treatment of Covid-۱۹.Methods: The present study is a multicenter, double-blind, randomized clinical trial study, which was conducted in ۴ medical centers. The study population includes all hospitalized patients with covid-۱۹ who met the study inclusion criteria. The data collection tool was a checklist including: ۱- demographic information, ۲- vital signs, symptoms, CT scan changes, drug side effects (neural, cardiac and respiratory) at the beginning of admission and from the first to ۱۰th day.Result: There was no significant difference between the intervention and control groups in the study of demographic variables, vital signs, symptoms, CT scan changes, and drug side effects before using PHR-۱۶۰ spray (P>۰.۰۵). Also, after using PHR-۱۶۰ spray for ten days, there was no significant difference in in the admission to the intensive care unit, and patient mortality in the two groups (P>۰.۰۵)Conclusion: Based on the results , PHR-۱۶۰ spray has no beneficial effects in controlling the symptoms of patients with covid-۱۹ and cannot play a effective role in improving the patient's condition and reducing the complications caused by the disease.Keywords: PHR-۱۶۰ spray , Covid-۱۹ , treatment , patient.

Keywords: PHR-۱۶۰ spray, COVID-۱۹, treatment, Patient