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The Relationship Between Positive Cultures With Multidrug-Resistant Microorganisms and Mortality in a General Intensive Care Unit

عنوان مقاله: The Relationship Between Positive Cultures With Multidrug-Resistant Microorganisms and Mortality in a General Intensive Care Unit
شناسه ملی مقاله: JR_JCMI-9-2_003
منتشر شده در در سال 1401
مشخصات نویسندگان مقاله:

Bahareh Marghoob - Department of Nephrology, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran
Malihe Khosravi-Khezri - Department of Clinical Pharmacy, Hasheminejad Kidney Center, Iran University of Medical Sciences, Tehran, Iran

خلاصه مقاله:
Aim: The patients in the intensive care unit (ICU) are more susceptible to healthcare-associated infections (HAI). Higher rates of nosocomial infections in ICU patients are associated with higher morbidity, mortality, and costs. The primary outcome of our study was to investigate the relationship between antibiotic resistance and mortality in ICU patients, and the secondary outcome was to evaluate the relationship between antibiotic resistance and the length of ICU or hospital stay. Methods: A ۵-year observational retrospective study was conducted on patients in the ICU of Hasheminejad Kidney Center affiliated with Iran University of Medical Sciences, Tehran, Iran from January ۱, ۲۰۱۵, to January ۱, ۲۰۲۰. The data related to age, gender, admission type, comorbidities, length of ICU stay, length of hospital stay, infection source, microorganism type, and resistance pattern of all isolates and outcomes were collected based on the study purpose. Results: During the ۵-year study, ۲۸۹۹ patients were admitted to the ICU, but only ۷۴۷ patients were enrolled in the study, including ۴۲۶ males (۵۷%). The median age was ۶۵ years (۱۹-۹۷ years). The mean length of ICU stay was greater in culture-positive patients (۸.۴۲ vs. ۳.۵ days, P > ۰.۰۰۱). Culture-positive patients had significantly higher mortality compared to culture-negative patients (۶۳.۸% vs. ۳۶.۲%, P > ۰.۰۰۱). In our study, it was found that resistant microorganisms have increased mortality by ۲.۶ times in the ICU in the crude model (OR: ۲.۶, P > ۰.۰۰۱). Conclusion: The findings of our study suggest that multidrug-resistant pathogens increase ICU stay and mortality.

کلمات کلیدی:
Intensive Care Unit, Mortality, Resistant microorganisms

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1700771/