Elevated Levels of Anti-SARS-Cov۲ IgG Antibody in Health Care Workers in Hospitals From Hamadan Province, Iran: A Prospective Study
عنوان مقاله: Elevated Levels of Anti-SARS-Cov۲ IgG Antibody in Health Care Workers in Hospitals From Hamadan Province, Iran: A
Prospective Study
شناسه ملی مقاله: JR_JCMI-9-2_007
منتشر شده در در سال 1401
شناسه ملی مقاله: JR_JCMI-9-2_007
منتشر شده در در سال 1401
مشخصات نویسندگان مقاله:
Ebrahim Jalili - Department of Emergency Medicine, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
Saeid Bashirian - Department of Public Health, Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Reza Faryabi - Department of Public Health, Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Mina Noroozbeygi - Department of Immunology, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
خلاصه مقاله:
Ebrahim Jalili - Department of Emergency Medicine, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
Saeid Bashirian - Department of Public Health, Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Reza Faryabi - Department of Public Health, Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Mina Noroozbeygi - Department of Immunology, School of Medicine, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
Aim: Seroprevalence among health care workers (HCWs) has been estimated in different studies in various
regions and countries. This study aimed to screen the immunoglobulin M (IgM) and IgG seroprevalences
and to assess the durability of IgG seropositivity, as well as the incidence of subsequent severe acute
respiratory syndrome coronavirus ۲ (SARS-CoV-۲) infection in a group of Iranian HCWs.
Methods: This voluntary serological screening was prospectively performed on ۸۰۰ HCWs (۴۹۲ females
and ۳۰۸ males) in Hamadan between November ۲۰۲۰ and February ۲۰۲۱. Anti-SARS-CoV-۲ IgG and IgM
antibodies were assessed by the enzyme-linked immunosorbent assay method at two-time intervals.
Results: Overall, ۲۴۳ out of ۸۰۰ (۳۰.۳۸%) and ۶۶ (۸.۲۵%) cases were IgG and IgM seropositive at their first
antibody assessment, respectively. The male staff had a higher seroprevalence than females (۳۱.۴۹% vs.
۲۹.۶۷% for IgG, P = ۰.۵۹ and ۱۰.۳۹% vs. ۶.۹۱% for IgM, P = ۰.۰۸). Higher prevalences for both antibodies
were found in the age group of ۳۰-۳۹.۹ years (P = ۰.۱۲ and P = ۰.۰۵, respectively). In the second antibody
screening, ۸۱ (۵۶.۶%) cases were IgG seropositive. The mean titer of the first IgG antibody assessment in
seropositive cases was lower than that of the second titer (۲.۹۵ ± ۲.۰۷ vs. ۵.۰۸ ± ۴.۰۱ cut-off index (COI)
, P = ۱.۴×۱۰-۵). Moreover, the comparison of the first and second IgG titers among ۸۱ seropositive cases
demonstrated a significantly increased level of anti-SARS-CoV-۲ antibody (۵.۰۸ ± ۴.۰۱ vs. ۳.۴۹ ± ۲.۴۱ COI,
P = ۰.۰۰۲).
Conclusions: Our findings revealed that the mean level of the anti-SARS-CoV-۲ IgG antibody was
significantly increased in the seropositive individuals after ۲ months of follow-up.
کلمات کلیدی: Seroprevalence, Antibody, IgG, SARS-CoV-۲
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1700775/