Evaluation of Survival Rate and Associated Factors in Patients with Cervical Cancer: A Retrospective Cohort Study
عنوان مقاله: Evaluation of Survival Rate and Associated Factors in Patients with Cervical Cancer: A Retrospective Cohort Study
شناسه ملی مقاله: JR_JRHSU-22-2_008
منتشر شده در در سال 1401
شناسه ملی مقاله: JR_JRHSU-22-2_008
منتشر شده در در سال 1401
مشخصات نویسندگان مقاله:
Fatemeh-Sadat Tabatabaei - MD, Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Arefeh Saeedian - MD, Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran- Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Amirali Azimi - MD, Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran-School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Kasra Kolahdouzan - MD, Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
خلاصه مقاله:
Fatemeh-Sadat Tabatabaei - MD, Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Arefeh Saeedian - MD, Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran- Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Amirali Azimi - MD, Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran-School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Kasra Kolahdouzan - MD, Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran- School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Background: Cervical cancer, the most common gynecological cancer, is a matter of concern, especially in
developing countries. The present study investigates survival rates, associated factors, and post-treatment
follow-up status in cervical cancer patients.
Study Design: A retrospective cohort study.
Methods: This study was conducted on ۱۸۷ patients referred to an academic referral cancer center in Iran
from ۲۰۱۴-۲۰۲۰. Overall survival (OS) and event-free survival (EFS) were evaluated using Kaplan Meyer
analysis. The event was defined as recurrence, metastasis, or death.
Results: The patients came for post-treatment visits for a median of ۳۶ months (interquartile range [IQR]:
۱۸-۵۱). The median OS and EFS were ۲۴ and ۱۸ months, respectively. The ۱- and ۳- year OS rates were
۹۰% and ۷۲%, respectively. The ۱- and ۳- year EFS rates were ۷۶% and ۶۱%, respectively. Stage ≥ III
(hazard ratio [HR]: ۳.۱, ۹۵% confidence interval [CI]: ۱.۵, ۶.۵, P < ۰.۰۰۱) and tumor size > ۴ cm (HR: ۲.۵,
۹۵% CI: ۱.۲, ۴.۹, P = ۰.۰۰۶) predicted lower OS. The most common histopathology was squamous cell
carcinoma (SCC) (۷۱.۱%) with non-significant higher ۳- year OS (HR: ۰.۶۲, ۹۵% CI: ۰.۳۳, ۱.۱۶, P = ۰.۱۳).
No significant difference in OS was found between adjuvant and definitive radiotherapy in both early and
advance-staged patients (Log-rank = ۰.۷ P = ۰.۴, log-rank = ۱.۶, P = ۰.۲, respectively).
Conclusion: As evidenced by the obtained results, the survival of patients was lower compared to that in
developed countries. Higher stage and tumor size led to shorter survival. The histopathology and type of
treatment in comparable stages did not have any significant impact on survival.
کلمات کلیدی: Neoplasm Staging, Survival Analysis, Adjuvant Radiotherapy, Uterine Cervical Neoplasm
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1700844/