Mehdi Raadabadi - PhD Candidate in Health Economics, Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Ali Darvishi - PhD Candidate in Health Economics, Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Batoul Ahmadi - Pharm.D-PhD, Department of Health Management and Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Fatemeh Soleymani - Pharm.D-PhD, Department of Pharmaco economics and Pharmaceutical Management, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Background: Antibiotics contribute to a lot of patients’ treatment. However, improper prescription and wasteful use of antibiotics may lead to various side effects or complications such as medicinal resistance and lack of treatment, resulting in an excessive financial burden. Objectives: The present study aimed to compare antibiotics prescription pattern and their financial burden before and after intervention based on prophylactic antibiotics guidelines in traumatic surgical sections. Methods: This analytical and cross-sectional study was conducted in ۲۰۱۸ on patients undergoing surgery in ۴ general, urology, neurosurgery, and orthopedics surgery sections. The sample consisted of ۴۶۴ patients with traumatic injuries. A researcher-made questionnaire was used as a principal instrument for gathering data. The data was analysed using SPSS (version ۲۱). Results: The accordance of dose, method and kind of prescribed antibiotics with the instructions and guidelines after intervention increased to ۲۹, ۵.۱ and ۲۸.۸%, respectively. There was a significant relationship between dose, method, and kind of prescribed antibiotic before and after the intervention (p <۰.۰۵). The financial burden of prescribed antibiotics before and after the intervention was ۵۶۴۰۰۴۸۰ and ۵۲۷۸۹۲۹۰ IRR, respectively. Conclusion: Based on the results, the intervention was effective in accordance with dose, method and kind of prescribed antibiotics. Also, financial burden reduced by ۶.۴% after the intervention. Continuous monitoring of antibiotic prescription based on instructions, training instructions of prophylaxis antibiotics to physicians, and infectious monitoring committee meetings can prevent irrational prescriptions and reduce the excessive financial burden on society, government and insurance organizations.

Prescription Pattern, Antibiotic Resistance, Traumatic injuries, Guidelines of prophylactic antibiotic, financial burden