Determination of the incidence of cardiovascular composite events in Patients with Obstructive Sleep Apnea: A ۳-year follow-up

Publish Year: 1402
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_RYA-19-2_002

تاریخ نمایه سازی: 15 مرداد 1402

Abstract:

Background: The occurrence of obstructive sleep apnea (OSA) and its health-related issues, especially cardiovascular diseases (CVD), are increasing in developing countries. With a ۳-year follow-up study, the present study aimed to determine the incidence of cardiovascular events in patients with OSA in an Iranian population.Methods: In this prospective cohort study, ۴۱۵ adults (۳۰۰ patients with OSA and ۱۱۵ patients without OSA) with a history of snoring and/or witnessed apneas or other suspected sleep breathing disorders were consecutively enrolled and followed up for three successive years to evaluate the development of cardiovascular events including acute coronary syndrome, cerebrovascular accidents (including ischemic or hemorrhagic strokes or transient ischemic attacks), death due to cardiac causes and all-cause mortality. Results: ۴۱۵ patients were studied with a mean age of ۵۶.۲ ±۱۵.۷ years, ۲۱۱ (۵۰.۸) of whom were male. Cardiovascular events developed in ۱۵ participants (۵%) of the OSA group, and ۳ participants (۲.۶ %) of the OSA negative group. No significant differences were observed between the two groups in terms of the incidence of any of these events (P-value> ۰.۰۵). Using multiple logistic regression model (with P-value <۰.۲ as the significance level), age, OSA, and history of CVD remained as significant predictors for the development of cardiac composite events (incidence of CVD, CVA, death due to cardiac causes, and all-cause mortality) with the odds ratios of (۹۵% confidence interval) ۱.۰۳ (۱.۰۱, ۱.۰۶), ۲.۴۱ (۱.۰۲, ۵.۷۶), and ۷.۴۰ (۲.۹۱, ۱۸.۶۷), respectively.Conclusions: The present study showed that OSA is associated with a more than twofold increased risk of cardiovascular events. Thus, obstructive sleep apnea should be considered an independent cardiovascular risk factor.

Authors

Sayed Mohammad Amin Sayedain

MD, Heart failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Saedeh Bahrani

MD, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Asieh Mansouri

Assistant professor, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Jamshid Najafian

Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Mohaddeseh Behjati

MD, Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Shahin Shirani

Assistant professor, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Babak Amra

Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Mohammad Emami Ardestani

Associate Professor, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Maryam Khosravi

Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Alireza Khosravi

Professor, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

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