Shirin Sarejloo - Al-Zahra Charity Hospital, Department of Cardiology Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Fatemeh Dehghani - Al-Zahra Charity Hospital, Department of Cardiology Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Reza Hatamnejad - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Soodeh Jahangiri - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Tahereh Ghaedian - Al-Zahra Charity Hospital, Department of Cardiology Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Salimi - Shiraz University of Medical Sciences, Shiraz, Iran
Hamed Bazrafshan Drissi - Al-Zahra Charity Hospital, Department of Cardiology Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Background: Autonomic nervous system dysfunction in diabetic patients can result in an atypical presentation of cardiovascular disease that can be missed. We aimed to use single-photon emission computed tomography (SPECT) to assess cardiovascular disease (CAD) in diabetic patients with atypical pain to determine whether the pain above reflects the CAD. Methods: Diabetic patients with atypical cardiac symptoms were referred to the SPECT department. Demographic data such as age, gender, diabetes status, and other underlying diseases were gathered. A myocardial perfusion scan was then performed. The results were recorded to evaluate the risk of myocardial ischemia and the degree of coronary artery involvement in a non-invasive manner. Results: The study included ۲۲۲ (۱۷۷ female) subjects with mean ages of ۶۳.۰۱±۱۱.۶۲ and ۵۹.۴۱±۹.۱۹ in positive and negative SPECT, respectively. The most common symptoms were atypical chest pain (۵۱.۸%), followed by shortness of breath (۵۰.۵%), nausea, and syncope (۰.۹%). Cardiac parameters, such as the summed stress score (SSS), summed rest score (SRS), total perfusion deficit in stress (TPD-s), total perfusion deficit in rest (TPD-r), were significantly higher in the group with coronary artery involvement (P<۰.۰۰۱). However, ejection fraction (EF), end-diastolic volume (EDV), and end-systolic volumes (ESV) parameters were not (P=.۰.۳۲۸, ۰.۳۵۱, and ۰.۴۴۳, respectively).Conclusions: The mere presence of diabetes does not necessitate any additional diagnostic tests beyond those required for the general population, and it is possible to follow a diagnostic course similar to that of the general population.

Diabetes Mellitus, Coronary Artery, Myocardial perfusion scan, Atypical Presentation, Atherosclerosis