Solubility Prediction of Pharmaceutical Compounds in Supercritical CO2 Based on Cubic Equation-of-State
Publish place: The 14th Conference of chemical Engineering
Publish Year: 1391
نوع سند: مقاله کنفرانسی
زبان: English
View: 1,290
This Paper With 5 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
NICEC14_107
تاریخ نمایه سازی: 3 آذر 1391
Abstract:
Supercritical fluid technology has emerged as an important technique for various applications including production of controlled drug delivery systems, powder processing, crystallization processes and supercritical fluid extraction (SFE). The solubility of solid compounds in supercritical fluids plays an important rule for design of processes and major difficulty in utilizing this processes has been the difficulty in measurement and prediction of their solubilities in supercritical solvents at various pressures and temperatures for process optimization. In this investigation, the solubility of Salicylic acid, Flubiprofen and some statin drugs in Supercritical CO2 (SC-CO2) at different pressures and temperatures were correlated using the Peng-Robinson (PR), Soave-Redlich-Kwong (SRK) equations-of-state with van der Waals (vdW) mixing rule
Keywords:
Authors
Kiarash Keshmiri
School of chemical engineering, College of Engineering, University of Tehran, Tehran, Iran
Alireza Vatanara
Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :