Setila Dalili - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Ghazaleh Aldaghi - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Shahin Koohmanaee - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Maryam Shahrokhi - Department of clinical pharmacy, Faculty of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
Mohammad Esfandiari - ۱. Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran ۲. Student research committee, Virtual School of Medical Education and Management, Shahid Beheshti University of Medical Sciences, Tehran,
Seyed Nemati - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Jafar Aldaghi - Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Afagh Hassanzadeh Rad - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
Houman Hashemian - Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran

Background: limited studies have been conducted on the effect of synbiotics supplementation on Type ۱ Diabetes Mellitus (T۱DM). The current study aimed to evaluate the impacts of synbiotic supplementation on glycemic parameters, lipid profile, and vitamin D levels in children with T۱DM.Methods: In this double-blind, randomized controlled trial, ۸۶ T۱DM patients aged ۴-۱۸ were randomly divided into two equal groups. One group received insulin and a synbiotic supplement once daily for ۱۲ weeks; another group received insulin and a placebo. FBS (fasting blood sugar), HbA۱C (hemoglobin A۱c), triglycerides, cholesterol, HDL (High-density lipoprotein), LDL (low-density lipoprotein), and vitamin D levels were measured at the beginning and end of the study in both groups.Results: The trend of FBS, HbA۱C, triglycerides, cholesterol, HDL, LDL, and vitamin D changes was not significant over time in both groups. Based on the analysis of covariance, the means of FBS and HbA۱C were lower in the intervention group (p=۰.۰۴۸ and ۰.۰۲۵, respectively). However, no significant changes in triglycerides, cholesterol, HDL, LDL, and vitamin D levels were observed between the two groups (p= ۰.۲۹۱, ۰.۲۹۱, ۰.۹۵۲, ۰.۱۴۰, and ۰.۵۵۷, respectively).Conclusion: It's suggested that insulin treatment in combination with synbiotic supplementation could improve FBS and HbA۱C in T۱DM children but had no effects on lipid profile and vitamin D levels.

Type ۱ Diabetes Mellitus,,, ,،Synbiotics,,, ,،Glycemic parameters,,, ,،Lipid profile