Ramin Javahershenas - Faculty of Chemistry, Urmia University, ۵۷۵۶۱۵۱۸۱۸, Urmia, Iran
Jabbar Khalafy - Faculty of Chemistry, Urmia University, ۵۷۵۶۱۵۱۸۱۸, Urmia, Iran

A green approach to synthesis of the polyfunctionalized pyrazole [۴′,۳′:۵,۶]pyrido[۲,۳-d] pyrimidines derivatives was successfully achieved via one-pot, four component reactions of β-aminocrotonitrile, phenyhydrazine, arylglyoxals, barbituric acid derivatives in the presence of TEA (Triethylamine) as a catalyst in water under the reflux conditions. This protocol provided mild reaction conditions, short reaction times, high yields, low cost, easy isolation of products and possible biological, and pharmaceutical activities.

β-Aminocrotonitrile Arylglyoxal ۱, ۳-Dimethylbarbituric acid Thiobarbituric acid TEA (triethylamine)