Puput Ade Wahyuningtyas - Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya ۶۰۱۱۵, Indonesia
Djoko Legowo - Faculty of Veterinary Medicine, Airlangga University, Mulyorejo Street, Surabaya ۶۰۱۱۵, Indonesia
Eka Pramyrtha Hestianah - Faculty of Veterinary Medicine, Airlangga University, Mulyorejo Street, Surabaya ۶۰۱۱۵, Indonesia
Hani Plumeriastuti - Faculty of Veterinary Medicine, Airlangga University, Mulyorejo Street, Surabaya ۶۰۱۱۵, Indonesia
Dinar Adriaty - Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya ۶۰۱۱۵, Indonesia
Iswahyudi Iswahyudi - Institute of Tropical Disease, Airlangga University, Mulyorejo Street, Surabaya ۶۰۱۱۵, Indonesia
Ratna Wahyuni - Department of Health, Faculty of Vocational Studies, Airlangga Univesity, Surabaya ۶۰۱۱۵, Indonesia
Medhi Denisa Alinda - Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya ۶۰۲۸۶, Indonesia
Cita Rosita Prakoeswa - Department of Dermatology and Venereology, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya ۶۰۲۸۶, Indonesia

The food industry in Indonesia still uses chemicals in food products. Borax is a chemical substance that has long been abused by the food industry to reach high profits at low production costs. This toxic material will cause damage and necrosis of liver cells. This research aimed to investigate the protective effect of tomato paste on liver histopathological changes exposed to sodium tetraborat or borax. This study used thirty-six healthy male mice two months old with a body weight of ۲۰ grams that were divided into six treatment groups for ۱۷ days and initial three days treatment was as follows. Group P۰ has been given sterile aqua dest for ۰.۱ ml/۲۰ g, group P۱ has been given borax for ۵.۶ mg/۲۰ g, group P۲ has been given tomato paste for ۲۳۰ mg/۲۰ g, and groups P۳, P۴, and P۵ were prevented by tomato paste for ۱۱۰ mg/۲۰ g, ۲۳۰ mg/۲۰ g, and ۳۵۰ mg/۲۰ g daily. For the next ۱۴ days, groups P۳, P۴, and P۵ have been exposed to borax every day as much as ۵.۶ mg/ ۲۰ g while groups P۰, P۱, and P۲ had the same treatment as before. On the ۱۸th day, the mice were sacrificed by cervical dislocation, followed by liver sample collection. This research showed that lycopene in tomato paste likely protected the liver from borax because the IL-۲ expression was decreased. It can be concluded that P۵ group offers the best protection against borax-exposed liver. It is necessary to carry out further research regarding the protection of tomato paste on borax exposure in other organs.

Borax, Interleukin-۲ Liver Tomato paste