Maroti Dhange - Department of Chemistry, Degloor College, Degloor, Nanded-۴۳۱۷۱۷ Maharashtra, India
Shivaji Patwari - Department of Chemistry, L.B.S. College, Dharmabad, Nanded, Maharashtra, India
Nitishkumar Kaminwar - Department of Chemistry, L.B.S. College, Dharmabad, Nanded, Maharashtra, India
Balaji Madje - Department of Chemistry, Vasantrao Naik College, Aurangabad-۴۳۱۰۰۳, Maharashtra, India
Dhanji P. Rajani - Microcare Laboratory and Tuberculosis Research Center, Surat-۳۹۵۰۰۳, Gujrat, India
Rajkumar Pokalwar - Department of Chemistry, Degloor College, Degloor, Nanded-۴۳۱۷۱۷ Maharashtra, India

The copper nanoparticles grafted on carbon microsphere (Cu-NP/C) catalyst was used to create a convenient and efficient synthesis of ۳-(۱H-benzo(d)imidazole-۲-yithio) methyl-۲-chloroquinoline (۴a-f) from ۲-Chloroquinoline-۳-carbaldehyde (۱a-f) and ۱H-benzo[d]imidazole-۲-thiol (Scheme-۱, Table-۲). The synthesis was placed under mild reaction conditions, resulting in a excellent yield (۹۲-۹۷%, Table-۲) of the appropriate compounds. The prepared compounds were characterized by H۱NMR, IR, and Mass spectroscopy. These synthesized compounds were studied for antituberculosis activities (Table-۳, ۴a-f) against standard drug isoniazid and rifampicin and show moderate activity. To explain the experimentally discovered affinity for ۳-((۱H-benzo[d]imidazol-۲-ylthio)methyl)-۲-chloroquinoline derivatives, molecular docking studies were conducted. A molecular docking study reveals the ۴e and ۴f derivatives of ۳-((۱H-benzo[d]imidazol-۲-ylthio)methyl)-۲-chloroquinoline to be the most active ones.

۳-(۱H-benzo(d)imidazole-۲-yithio)methyl-۲-chloroquinoline, ۲-chloroquinoline-۳-carbaldehyde, Antituberculosis Activity, Molecular docking, ۱H-benzo[d]imidazole-۲-thiol, Copper Nanoparticles Grafted on Carbon Microspheres